Multimodal Neural Response and Effect Assessment During a BCI-Based Neurofeedback Training After Stroke.

Abstract

Stroke caused by cerebral infarction or hemorrhage can lead to motor dysfunction. The recovery of motor function is vital for patients with stroke in daily activities. Traditional rehabilitation of stroke generally depends on physical practice under passive affected limbs movement. Motor imagery-based brain computer interface (MI-BCI) combined with functional electrical stimulation (FES) is a potential active neural rehabilitation technology for patients with stroke recently, which complements traditional passive rehabilitation methods. As the predecessor of BCI technology, neurofeedback training (NFT) is a psychological process that feeds back neural activities online to users for self-regulation. In this work, BCI-based NFT were proposed to promote the active repair and reconstruction of the whole nerve conduction pathway and motor function. We designed and implemented a multimodal, training type motor NFT system (BCI-NFT-FES) by integrating the visual, auditory, and tactile multisensory pathway feedback mode and using the joint detection of electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS). The results indicated that after 4 weeks of training, the clinical scale score, event-related desynchronization (ERD) of EEG patterns, and cerebral oxygen response of patients with stroke were enhanced obviously. This study preliminarily verified the clinical effectiveness of the long-term NFT system and the prospect of motor function rehabilitation.