Abstract
The present study introduces a recently developed compact hybrid device for real-time monitoring of skin oxygen saturation and temperature distribution. The prototype involves a snapshot hyperspectral camera, multi-wavelength illuminator, thermal camera, and built-in computer with custom-developed software. To validate this device in-vivo we performed upper arm vascular occlusion on eight healthy volunteers. Palm skin oxygen saturation maps were analyzed in real-time using k-means segmentation algorithm and two-layer optical diffuse model. The prototype system demonstrated a satisfying performance of skin hyperspectral measurements in the spectral range of 507–625 nm. The results confirmed the reliability of the proposed system for in-vivo assessment of skin hemoglobin saturation with oxygen and microcirculation.
Highlights
Over the last decades, there has been growing evidence that human cutaneous microcirculation can reflect different aspects of neuro-immuno-endocrine functions and may serve as an early marker for various pathological conditions such as diabetes [1,2], systemic rheumatic disease [3,4], neuropathy [5], and sepsis [6,7]
The quality of spectral response was measured by calculating area under curve (AUC) of normalized spectra
The present study introduces a recently developed multimodal device prototype for dual-modality microcirculation assessment using visible range hyperspectral imaging (HSI) and thermography
Summary
There has been growing evidence that human cutaneous microcirculation can reflect different aspects of neuro-immuno-endocrine functions and may serve as an early marker for various pathological conditions such as diabetes [1,2], systemic rheumatic disease [3,4], neuropathy [5], and sepsis [6,7]. The disturbance of blood supply leads to impairments of cutaneous oxygen saturation, which is one of the most essential vital parameter in the assessment of tissue health. A potential technique for non-invasive assessment of mottled skin patches is hyperspectral imaging (HSI) [9]. The technique is based on the acquisition of multiple images within relatively narrow non-overlapping spectral bands. The light delivered to biological tissue undergoes multiple scattering and absorbance from inhomogeneities of biological structures. Assessing the concentrations of these chromophores can be used to identify pathological changes in the skin. The advantage of HSI over the convenient diffuse reflectance spectroscopy (DRS) is the possibility of measuring the spatial distribution of skin chromophores as well as obtaining spectral information.
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