Abstract
The aim of this research was to evaluate the genetic diversity within and between C. albicans populations isolated from the oral cavity of healthy Brazilian children classified into five socioeconomic categories (A to E). Multilocus Enzyme Electrophoresis (MLEE) analysis was the method used to assess genetic diversity. High genetic diversity was observed in all populations that showed predominance of some C. albicans subtypes (Electrophoretic Types - ETs). However, no correlation was observed between a specific ET and a specific population of children. Clustering analysis showed one or more highly related ET clusters, suggesting the existence of indirect and direct propagation routes of C. albicans among healthy children. Microevolutionary changes were observed in some C. albicans populations isolated from children with the same or very similar socioeconomic condition. Furthermore, low transition of C. albicans subtypes can be occurring among certain populations of children coming from high and medium/high, or high and medium/low, or medium/high and medium/low socioeconomic categories, which can also be explained by their own socioeconomic and cultural characteristics.
Highlights
O objetivo desta pesquisa foi avaliar o grau de diversidade genética dentro e entre populações de C. albicans isoladas da cavidade bucal de crianças saudáveis brasileiras classificadas em cinco categorias socioeconômicas (A até E), através da análise de Eletroforese de Enzimas Multilocos (MLEE)
The aim of this research was to evaluate by Multilocus Enzyme Electrophoresis (MLEE) and clustering analysis, the genetic diversity in C. albicans populations isolated from the oral cavity of healthy Brazilian children classified into five socioeconomic categories (A, B, C, D, and E)
The study involved 75 C. albicans samples isolated from the oral cavity of 75 clinically healthy children, with ages varying between six and nine years, of both genders, classified into 5 socioeconomic categories (A = 19, B = 17, C = 15, D = 12, and E = 12) according to the criteria adopted by the Brazilian Association of Advertisers and by the Brazilian Institute of Market Research (ABA/ABIPEME), from the municipal district of Piracicaba, State of São Paulo, Brazil[41]
Summary
O objetivo desta pesquisa foi avaliar o grau de diversidade genética dentro e entre populações de C. albicans isoladas da cavidade bucal de crianças saudáveis brasileiras classificadas em cinco categorias socioeconômicas (A até E), através da análise de Eletroforese de Enzimas Multilocos (MLEE). Alta diversidade genética foi observada em todas as populações, as quais mostraram predominância de alguns subtipos de C. albicans (Tipos Eletroforéticos – ETs). A existência de um ou mais grupos de ET altamente relacionados foi mostrada pela análise de agrupamento, o que sugere a existência de rotas de propagação direta e indireta de C. albicans entre crianças saudáveis. Baixa transição de subtipos de C. albicans podem estar ocorrendo entre certas populações de crianças provenientes de alta e média/alta, ou alta e média/baixa, ou média/alta e média/ baixa, categorias socioeconômicas, o que pode ser esclarecido pelas suas próprias características socioeconômica e cultural
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