Multigenic polymorphism as a source of adaptively restricted population variability

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Among 400 Drosophila melanogaster flies individually analysed for nine gene–enzyme systems, a total of 160 different genotypes were found: 78 were repeatedly observed in two to 22 individuals, and 82 appeared only once. An increase in the frequency of rare alleles could be observed in such groups of genotypes that were less frequent. Among 24 most frequent genotypes (in 189 individuals) only four different combinations of five third-chromosomal genes are present, and 12 different combinations of three second-chromosomal genes. Among 82 unique genotypes these combinations were much more versatile: 29 at the third, 22 at the second, and three at the first chromosomes. The proportion of heterozygotes was increasing from most frequent toward unique genotypes (1.5–2.1 ± 0.1), primarily due to heterozygosity in five third-chromosomal loci (0.4–1.1 ± 0.06). When the number of genotypes in 100, 200, 300 and 400 sampled flies was extrapolated to larger samples, it became clear that this increase has an asymptotic character. It must be assumed that for our nine-loci model a total of approximately 200–220 different genotypes may exist in a population of a few thousands individuals, which means that adaptive variation for such a complex gene–enzyme system must be very much limited.