Abstract
Chronic infected wounds present significant challenges globally, as persistent bacterial colonization would lead to prolonged inflammation, impaired tissue repair, etc. This study describes a novel MMP-responsive GelMA hydrogel dispersed with AgNPs and Res co-loaded cationic silicasomes for chronic infected wound treatment. The resulting silicasomes-GelMA hydrogel could firmly adhere to the wound surface, rapidly absorb the blood and exudate from the wound. GelMA was gradually degraded by the over-expressed MMP9 enzymes in the wound environment. The released silicasomes could effectively eradicate MRSA by targeting bacterial cell walls and membranes, with intracellular bacterial clearance rate of 83.75%-88.14%, which promoted the angiogenesis and re-epithelialization process, reduced inflammatory response, and achieved nine times higher neovasculation and half shortened skin barrier regeneration period. Collectively, our designed silicasomes-GelMA hydrogel could achieve hemostasis, anti-inflammation, antibacterial, and tissue regeneration effects simultaneously by a single dose, and is a promising drug delivery platform for chronic infected wound therapy.
Published Version
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