Abstract
Cells respond to many hormones, neurotransmitters and growth factors by increasing intracellular Ca 2+. This second messenger, in turn, affects cellular function via activation of a novel multifunctional Ca 2+/calmodulin-dependent protein kinase. The kinase displays an interesting form of biochemical ‘memory’; activation elicits an autophosphorylation which converts it to a Ca 2+-independent enzyme that can continue to phosphorylate cellular proteins for some time following termination of the initial Ca 2+ stimulus.
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