Abstract
Background: Multifocal acquired demyelinating sensory and motor polyneuropathy (MADSAM) is an autoimmune neuropathy manifested as asymmetric multifocal pattern of sensory and motor loss, initially involving the upper extremities. Electrophysiological studies reveal demyelinating features of CMAPs and abnormal SNAPs. CSF findings show elevated CSF protein and rarely show presence of GM1 antibodies. MADSAM responds to steroids and Intravenous immunoglobulin (IVIG) in 80% of cases.
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