Abstract
Multidrug-Resistant<i>Escherichia coli</i>Bacteremia
Highlights
We characterized 140 E. coli isolates from bacteremia patients treated at Nottingham University Hospital (Nottingham, UK) over a 5-month period, with the aim of developing an epidemiologic profile of the population of Extraintestinal pathogenic Escherichai coli (ExPEC) that causes bacteremia
Antimicrobial drug susceptibility tests, PCR detection of ESBL genes, multilocus sequence typing using the Achtman scheme, and virulence-associated gene (VAG) carriage screening by PCR were performed on isolates as described (7)
PCR screening for ESBL carriage showed significantly higher ESBL carriage in bacteremia E. coli isolates than urine isolates for blaSHV (15.7% vs. 5.6%; p = 0.008), blaCTX-M (29.3% vs. 17.6%; p = 0.025), and blaOXA (14.3% vs. 6.4%; p = 0.037)
Summary
We characterized 140 E. coli isolates from bacteremia patients treated at Nottingham University Hospital (Nottingham, UK) over a 5-month period, with the aim of developing an epidemiologic profile of the population of ExPEC that causes bacteremia. Antimicrobial drug susceptibility tests, PCR detection of ESBL genes, multilocus sequence typing using the Achtman scheme (http:// mlst.ucc.ie/mlst/dbs/Ecoli), and virulence-associated gene (VAG) carriage screening by PCR were performed on isolates as described (7). PCR screening for ESBL carriage showed significantly higher ESBL carriage in bacteremia E. coli isolates than urine isolates for blaSHV (15.7% vs 5.6%; p = 0.008), blaCTX-M (29.3% vs 17.6%; p = 0.025), and blaOXA (14.3% vs 6.4%; p = 0.037).
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