Multidrug-Resistant Pathogens in Wound Infections: A Systematic Review.

Abstract

This systematic review aimed to explore the antimicrobial activity of a silver-containing gelling fiber dressing against multidrug-resistant organisms (MDROs) in wound infections. Itparticularlyfocuses on burn wounds and evaluates its potential clinical significance in combating antimicrobial resistance. A comprehensive literature searchwas conductedacross multiple databases over the past ten years. Itis usedto identify relevant studies addressing MDRO infections in wound care and exploring novel antimicrobial approaches. The included studies underwent rigorous methodological assessment. Additionally, the datawere synthesizedto evaluate the efficacy of silver-containing dressings in inhibiting MDRO growth and eradicating biofilm-associated bacteria. Moreover, this review revealed that silver-containing dressings have constant in vitro antimicrobial activity against 10 MDROs over seven days in simulated wound fluid. However, inhibitory and bactericidal effectswere consistently observedagainst free-living and biofilm phenotypes. The findings suggest potential clinical significance in managing MDRO infections in wounds.Thishighlights its role in mitigating treatment failure and antimicrobial resistance. Despite the promising implications for wound management practices, this study acknowledges some limitations. In vitro models and the absence of direct clinical validation have also been included. However, the review explains the importance of new approaches. Nanotechnology hasbeen usedto address antimicrobial resistance in wound care. Thus, further research and innovation are needed to improve patient outcomes and combat antimicrobial resistance.