Multicomponent Reactions of Carbonyl Compounds and Derivatives of Cyanoacetic Acid: Synthesis of Carbo- and Heterocycles

Abstract

We present herein a review of multicomponent reactions of carbonyl compounds with derivatives of cyanoacetic acid, and denote their differences from other well-known multicomponent reactions. Although this class of multicomponent reactions is widely used in organic chemistry for the synthesis of carbo- and heterocycles, it has not yet been reviewed in a separate publication. This review includes available information on the synthesis of carbocycles (substituted cyclopropanes, spiro-conjugated cyclopropanes, five- and six-membered carbocycles), five-membered heterocycles (furans, thiophenes, pyrroles, thiazoles, and others), and six-membered heterocycles (pyrans, thiopyrans, and pyridines) using the multicomponent reaction of carbonyl compounds with derivatives of cyanoacetic acid. 1 Introduction 2 Multicomponent Carbocyclic Synthesis 2.1 Synthesis of Cyclopropanes 2.2 Synthesis of Five- and Six-Membered Carbocycles 3 Multicomponent Heterocyclic Synthesis 3.1 Synthesis of Five-Membered Heterocycles 3.2 Synthesis of Six-Membered Heterocycles 4 Conclusion