Abstract
An operationally simple multicomponent reaction utilizing (Z)-chloroximes, isocyanides and NH-heterocyclic rings (imidazole, benzimidazole, triazole, benzotriazole and tetrazole) affords a hitherto unknown class of compounds which cannot be obtained via a classical multistep two-component reaction. From this work, it appears evident: a) kinetic control dictated by the [3 + 1] cycloaddition between nitrile N-oxides and isocyanides; b) the chemical compatibility between the highly unstable nitrilium ion and the poorly nucleophilic imidazoles and related heterocycles, which quench the reaction allowing for the formation of a single product.
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