Abstract
An efficient multicomponent domino process that works under mild conditions was used for the synthesis of systematically modified neomycin–sugar conjugates. The final aminoglycoside derivatives were tested against methicillin-resistant Staphylococcus aureus , Klebsiella , and E. coli strains, and show activity comparable to the parent antibiotics. Such a strategy can impact multicomponent combinatorial syntheses of diverse biologically active conjugates.
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