Multicompartmental Mesoporous Silica/Polymer Nanostructured Hybrids: Design Capabilities by Integrating Linear and Star-Shaped Block Copolymers.

Zacharoula Iatridi,Nikolaos Theodorakis,Athina Angelopoulou,Konstantinos Avgoustakis,Constantinos Tsitsilianis,Kyriaki Evangelatou

doi:10.3390/polym12010051

Zacharoula Iatridi, Nikolaos Theodorakis + Show 4 more

Open Access

https://doi.org/10.3390/polym12010051

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Journal: Polymers	Publication Date: Dec 31, 2019
Citations: 5	License type: CC BY 4.0

Affiliation: University of Patras

Abstract

Poly(2-vinyl pyridine)-b-poly(ethylene oxide) (P2VP-b-PEO) linear diblock copolymer and polystyrene–poly(ethylene oxide) (PS10PEO10) heteroarm star copolymer were used as building elements to prepare organic–inorganic hybrids. By using the layer-by-layer (LbL) methodology, these elements were integrated on mesoporous silica through non-covalent interactions, namely, ionic and H-bonding. For the latter, tannic acid (TA) was used as an intermediate layer. The deposition of the various layers was monitored by thermogravimetric analysis (TGA), electrophoretic measurements, and confocal microscopy. The final silica hybrid, bearing alternating P2VP-b-PEO and PS10PEO10 star layers was capable of carrying one hydrophilic and two hydrophobic chemical species in distinct compartments. These multicompartmental organic–inorganic hybrids could be used as nanostructured carriers for pH-responsive multiple drug delivery and potential theranostic applications.

Highlights

The use of mesoporous silica particles (MSPs) as nanocarriers and promising platforms for delivery, diagnostic, or prognostic biomedical applications received tremendous attention from the scientific community
tannic acid (TA) is a polyphenol with characteristic antioxidant, anticarcinogenic, antimicrobial, and antibacterial properties that can interact with various molecules through several mechanisms [35,36,37,38,39]
It was used with the LbL technique forming multilayer assemblies via hydrogen bonding with pH-responsive, thermo-responsive, or neutral polymers including TA/poly(allylamine) (PAH) [36], TA/poly(N-vinylpyrrolidone) (PVPON) [40,41,42,43], TA/poly(ethylene oxide) (PEO), TA/poly(ethylene glycol) (PEG) [44,45,46], TA/poly(N-vinylcaprolactam)

Summary

Introduction

The use of mesoporous silica particles (MSPs) as nanocarriers and promising platforms for delivery, diagnostic, or prognostic biomedical applications received tremendous attention from the scientific community. MSPs usually suffer from premature release of the encapsulated payload and leakage before reaching the targeted site To overcome such barriers and confer together other advantageous properties including improved surface functionalities, switchability, responsiveness, or better stability, mesoporous silica nanoparticles (MSNs) are modified by polymers [9,10]. TA is a polyphenol with characteristic antioxidant, anticarcinogenic, antimicrobial, and antibacterial properties that can interact with various molecules through several mechanisms (electrostatic interactions, hydrophobic interactions, hydrogen bonding, etc.) [35,36,37,38,39] It was used with the LbL technique forming multilayer assemblies via hydrogen bonding with pH-responsive, thermo-responsive, or neutral polymers including TA/poly(allylamine) (PAH) [36], TA/poly(N-vinylpyrrolidone) (PVPON) [40,41,42,43], TA/poly(ethylene oxide) (PEO), TA/poly(ethylene glycol) (PEG) [44,45,46], TA/poly(N-vinylcaprolactam). By integrating pH-responsive block copolymers and monomolecular star-based micelles into the MSP, novel functional materials can emerge as multicompartmental carriers for multiple drug delivery and theranostic potential applications

Materials

Encapsulation of Nile Red or Pyrene in PS10 -PEO10 Micelles

Techniques

Results and Discussion

Confocal microscopy

Hybrids with Alternating P2VP-b-PEO and PS10 -PEO10 Layers

Conclusions