Abstract
Mimicking the green fluorescent protein (GFP), multicolor fluorescent polymers possessing enhanced fluorescence have been developed and applied to single-excitation cell imaging. The GFP core chromophore was covalently linked to the azide-functionalized amphiphilic block polymer poly(ethylene glycol)–azide–poly(methyl methacrylate). Through macromolecular assembly into micelles, the fluorescence enhanced and further increased with the elongation of poly(methyl methacrylate) chain due to the segmentation effect of the polymeric framework, which could reduce strong π–π interaction and suppress the chromophore’s conformational motion. By a combination of chemically tailoring the core chromophore and macromolecular assembly strategy, multicolor fluorescent polymers showing a color palette from blue to orange were achieved under similar excitation conditions with the highest emission quantum yield approaching 8%, which is more than 80-fold larger than that of the core chromophore. Moreover, fluorescent emissio...
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