Multicentre, randomised, double-blind, placebo-controlled, proof of concept study of LSALT peptide as prevention of acute respiratory distress syndrome and acute kidney injury in patients infected with SARS-CoV-2 (COVID-19)

Ranjani Somayaji,David R Luke,Arthur Lau,Rahmet Guner,Ŏ Fehmi Tabak,Mark Hepokoski,Nancy Gardetto,Steven A Conrad,Sunil D Kumar,Kalyan Ghosh,Stephen M Robbins,Donna L Senger,Daisy Sun,Rachel K S Lim,Jonathan Liu,Fatma Eser,Ridvan Karaali,Alain Tremblay,Daniel Muruve

doi:10.1136/bmjopen-2023-076142

Multicentre, randomised, double-blind, placebo-controlled, proof of concept study of LSALT peptide as prevention of acute respiratory distress syndrome and acute kidney injury in patients infected with SARS-CoV-2 (COVID-19)

Ranjani Somayaji, David R Luke + Show 17 more

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https://doi.org/10.1136/bmjopen-2023-076142

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Journal: BMJ Open	Publication Date: Mar 1, 2024
Citations: 1	License type: CC BY-NC 4.0

Affiliation: University of Calgary, University of California San Diego Medical Center, Jewish General Hospital

#Placebo Group #Ventilation-free Days #Need For Renal Replacement Therapy #Organ Dysfunction In Patients #Acute Kidney Injury In Patients #Intensive Respiratory Support #Changes In Kidney Function #Kidney Injury In Patients #Extracorporeal Membrane Oxygenation #Invasive Mechanical Ventilation

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ObjectiveDipeptidase-1 (DPEP-1) is a recently discovered leucocyte adhesion receptor for neutrophils and monocytes in the lungs and kidneys and serves as a potential therapeutic target to attenuate inflammation in moderate-to-severe...

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Multicentre, randomised, double-blind, placebo-controlled, proof of concept study of LSALT peptide as prevention of acute respiratory distress syndrome and acute kidney injury in patients infected with SARS-CoV-2 (COVID-19)