Abstract
The aim of the paper is the development of the conductometric biosensor systems based on differential method of measurements of local conductivity of the buffer solution in the working (active) and reference (passive) biochemical membranes. We used structural and algorithmic methods to improve the accuracy and speed of measurements, to increase functions and performance of the measuring instruments. Variants of construction of the measuring unit of a multibiosensor system with a differential conductometric transducers based on the balanced AC bridge are discussed. The proposed structure and working algorithms of the bridge circuits with a few work and a reference conductometric transducers provide them the automatic balancing together with diagnosis of efficiency of the sensors. It provides improved suppression of the noninformative impact of environmental factors on the measurement results. The advantages and disadvantages presented technical solutions have been analyzed; recommendations for their application have been given depending on the dynamics of the biochemical reactions and other requirements for the measurement system. The way to simplify the structure of the differential conductometric multisensor is shown. It was justified the possibility of creation of portable conductometric multibiosensor device, which suitable for mass production and practical application, based on previously developed standardized measurement modules.
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