Abstract
In this work, multi-walled carbon nanotubes were applied as sorbent for extraction, followed by back-extraction and HPLC/UV determination of Nalidixic acid in aqueous solutions. The effects of some parameters such as pH, flow velocity, sorbent amount, and ionic strength were investigated. A little amount of sorbent (5.0 mg) was chosen as its optimum amount which this sorbent was reusable for almost five cycles of adsorption/desorption processes. A preconcentration factor of 500 was obtained. Linear range was 0.19–23.2 mg L−1 (R2 = 0.9979). The limit of detection and RSD for the suggested method were 0.02 mg L−1 and 2.2%, respectively. To assess the method performance for real samples, Nalidixic acid was determined in human blood serum and tablet samples. Advantages of the suggested method for Nalidixic acid extraction and preconcentration are low cost, being less time consuming, simplicity, no usage of organic solvents, and high preconcentration factor and efficiency.
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