Abstract
Microparticles hydrogel sensitive to reduction, pH and radiation composed of starch (St) and MnO2 NPs were synthesized, and loaded with Dox for in vitro treatment of MCF-7 cells. LE and EE values were obtained as 3.12 and 93.4%, respectively. In vitro drug release study revealed pH- and reduction-responsiveness drug release behavior of the DDS. The intracellular uptake of the St/MnO2 microparticles was verified through FITC dye conjugation. The St-MnO2/Dox microparticles exhibited higher anticancer activity than free Dox after 48 h as verified by MTT and DAPI staining assays. As results, combined chemoradiotherapy approach exhibited synergistic outcomes than chemotherapy alone.
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