Abstract
E3 ubiquitin-linked enzyme MARCH5, also known as membrane-associated circular finger 5, is an enzyme encoded by the human MARCH5 gene. The main objective of this study was to visualize the prognosis of MARCH5 in breast cancer and to determine the relationship between MARCH5 expression and tumor immunity. MARCH5 expression was significantly higher in several cancers, including breast cancer (BRCA), compared with corresponding normal tissues. Not only was high MARCH5 expression associated with poorer overall survival, but also MARCH5 expression was positively correlated with the number of tumor-infiltrating immune cells in BRCA malignant tissues. Furthermore, MARCH5 expression showed a strong correlation with various immune markers of BRCA, suggesting its role in regulating tumor immunity. MARCH5 is a useful prognostic biomarker in several cancers, and its expression is highly correlated with tumor immune cell infiltration, and increased MARCH5 expression may serve as a new biomarker for BRCA diagnosis and prognosis.
Highlights
Breast cancer is one of the most common malignancies in women
We explored MARCH5 gene expression profiles by systematically analyzing the association of MARCH5 expression with the prognosis of breast cancer patients confirmed in multiple databases
Using the Oncomine dataset, we found that MARCH5 expression levels in the Ramaswamy multi-cancer dataset ranked first among cancers, with MARCH5 levels two times higher than those in normal tissues (Figure 1B)
Summary
Breast cancer is one of the most common malignancies in women. Despite the rapid advances in the treatment of breast cancer, its incidence remains high and has tended to increase year by year in recent years, with a trend toward younger age [1]. The causes and pathogenesis of breast cancer are complex and have not been fully understood by current research. The occurrence and development of malignant tumors is an extremely complex and changing process, which occurs with the joint participation and interaction of oncogenes [2]. When the immune function of the body is disrupted and the immune factor is abnormal, leading to the incompetence of immune surveillance, it leads to the occurrence and development of malignant tumor [3,4]
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