Multi-level programmable photodynamic system with synergistic sequential chemotherapy

Abstract

An ideal antitumor drug delivery system with multi-level programmable drug release function should obtain significant synergestic antitumor efficacy by distinct mechanisms and rarely MDR occur during the treatment period. Long duration of drug efflux inhibition during the whole drug release process could maximize the antitumor efficacy of chemotherapeutics1. Previous clinical trials have already demonstrated that combinations of two or more drugs were more effective in the cancer treatment than just one drug alone, especially photodynamic therapy (PDT) combing with sequential chemotherapy. In our study, PDTchemotherapeutic drug delivery systems composed of three carriers with different payloads and configurations were established based on self-decomposable SiO2 NPs (Figure 1).