Abstract
Mulberry, a natural source of flavonoids, phenolics and anthocyanins, has been widely used in edible food and medicine due to its pharmacological effect. Growing evidence indicates that gut microbiota contributes to obesity, type II diabetes and many other related metabolic disorders. The present study was designed to evaluate the influence of the mulberry water extract (ME) on high‐fat diet induced obesity and determine whether the beneficial effects of ME are associated with the modulation of gut microbiota. Forty‐five male C57BL/6J mice were divided into three groups and fed with low‐fat diet, high‐fat diet or high‐fat diet plus ME administration of 300 mg/kg/day for 15 weeks. 16S rDNA sequencing was performed to analyze the composition of gut microbiota. Our results showed that dietary ME reduced HFD‐induced body weight gain and ameliorated adipose tissue hypertrophy and insulin resistance. Moreover, metagenomic analysis indicated that ME supplement significantly changed the ratio of Firmicutes and Bacteroidetes at the phylum level.In conclusion, ME protects from diet‐induced obesity and its related metabolic disorders, which is associated with the modulation of gut microbiota in mice. These findings suggested a dietary choice of mulberry in the nutrition therapy of obesity and its metabolic disorders.Support or Funding InformationNational Natural Science Foundation of China (Grant No. 31701031) China Postdoctoral Science Foundation (Grant No. 2016M601006)This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
Published Version
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