Abstract
This study was to evaluate the detoxification ability of mulberry crude extract against NP-induced toxic effects in rats. The structures of the main active substances in mulberry crude extract were first identified by HPLC-Q-TOF-MS. Male Sprague–Dawley rats were exposed to NP (270mg/kg) or/and mulberry crude extract (30, 60, 120mg/kg·bw) for 28days. Mulberry crude extract was found to contain 34.86mg/mL polyphenols and 7.39mg/mL flavonoids. GST and UGT2b1 in rat liver microsomes were inhibited by 270mg/kg NP, whereas their levels increased by 120mg/kg·bw mulberry crude extract treatment. The expression inhibition of Nrf2, GST and Ugt2b1 mRNA by 270mg/kg NP significantly improved by 120mg/kg·bw mulberry crude extract treatment. Taken together, mulberry crude extract may be an efficient detoxification agent against NP-induced toxic effects by activation of Nrf2 and Nrf2-related detoxifying enzymes in rat.
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