Abstract
Kaposi's sarcoma (KS) is an endothelial neoplasia caused by infection with the human herpesvirus 8 (HHV-8), and the type associated with the human immunodeficiency virus (HIV) is considered the most aggressive and frequent. This paper reports a case of mucocutaneous KS in a patient not formerly aware of being an HIV bearer. A 38-year-old male patient has sought treatment with multiple oral lesions and one in the skin. Serology was positive for HIV and incisional biopsy diagnosed KS. After 11 months of chemotherapy and antiretroviral therapy, there was complete remission of the skin KS and partial remission of oral lesions.
Highlights
Kaposi’s sarcoma (KS) is a malignant neoplasia of endothelial cell proliferation[1], considered as rare till the advent of acquired immune deficiency syndrome (Aids) in the 1980s(2, 3)
Kaposi’s sarcoma (KS) is an endothelial neoplasia caused by infection with the human herpesvirus 8 (HHV-8), and the type associated with the human immunodeficiency virus (HIV) is considered the most aggressive and frequent
This paper reports a case of mucocutaneous KS in a patient not formerly aware of being an HIV bearer
Summary
Kaposi’s sarcoma (KS) is a malignant neoplasia of endothelial cell proliferation[1], considered as rare till the advent of acquired immune deficiency syndrome (Aids) in the 1980s(2, 3). It has affected about 37% of male patients, with buccal manifestations in 50% of them[2]. The oncovirus human herpesvirus 8 (HHV-8)(4) is involved in the etiology of KS, being found in 90% of the diagnosed cases It seems to be associated with the production of interleukin-6 (IL-6), which produces a mitogenic effect, as well as the bcl-2 gene, a counterpart of the proto-oncogene bcl-2(2). The treatment varies between surgery for local lesions and radiotherapy in small doses and/or systematic or intralesional chemotherapy[2, 5]
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