Abstract
To overcome the problems like absorption of drug, hepatic first pass metabolism, drug targeting to specific organ, a novel approach is developed for delivery of drug i.e Insitu Nasal drug delivery system. Insitu based gel delivery system can bypass the blood brain barrier and deliver the drug to the desired site. Insitu gelling systems are liquid at room temperature however experience gelation when in contact with body fluids. Mucoadhesive insitu nasal gel have increase the residence time in the nasal cavity. Insitu gel development happens because of one or mix of various upgrades like pH change, temperature modulation and solvent exchange. The insitu gel formulations have several advantages like sustained and prolonged action as compare to conventional drug delivery system. This review will be focused on insitu based gels, various aspects of nasal anatomy and physiology, mechanism of nasal drug absorption, different components that impact nasal medication ingestion, assessment of nasal gel.
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