Abstract
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been reported to be associated with pancreatic cancer, but the published studies had yielded inconsistent results.We therefore performed the present meta-analysis. A search of Google scholar, PubMed, Cochrane Library and CNKI databases before April 2012 was conducted to summarize associations of MTHFR polymorphisms with pancreatic cancer risk. Assessment was with odds ratios (ORs) and 95% confidence intervals (CIs). Publication bias were also calculated. Four relative studies on MTHFR gene polymorphisms (C667T and A1298C) were involved in this meta-analysis. Overall, C667T(TT vs. CC:OR=1.61, 95%CI=0.78-3.34; TT vs. CT:OR=1.41, 95%CI=0.88-2.25; dominant model: OR=0.68, 95%CI=0.40-1.17; recessive model: OR=0.82, 95%CI=0.52-1.30) and A1298C(CC vs. AA:OR=1.01, 95%CI=0.47-2.17; CC vs. AC:OR=0.99,95%CI=0.46-2.14; dominant model: OR=1.01, 95%CI=0.47-2.20; recessive model: OR=1.01, 95%CI=0.80-1.26) did not increase pancreatic cancer risk. This meta-analysis indicated that MTHFR polymorphisms (C667T and A1298C) were not associated with pancreatic cancer risk.
Highlights
Pancreatic cancer is the tenth most common cause of cancer in the United States and is apparently the fourth leading cause of cancer mortality, it is estimated that 44030 new cases and 37660 associated deaths of the pancreatic cancer in 2011
We investigated whether or not the methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms is associated with pancreatic cancer by performing a meta-analysis
Several research studies have evaluated the association between MTHFR polymorphisms and pancreatic cancer, the specific association is still controversial
Summary
Pancreatic cancer is the tenth most common cause of cancer in the United States and is apparently the fourth leading cause of cancer mortality, it is estimated that 44030 new cases and 37660 associated deaths of the pancreatic cancer in 2011 (http://seer.cancer.gov/statfacts/html/ pancreas.html). Both genetic and environmental factors play a role in the in the development of the disorder. Two significant functional polymorphisms of the MTHFR gene (C677T and A1298C) have been related to a reduced enzyme activity and increased the risk of pancreatic cancer, the published results have been inconsistent (Frosst et al, 1995; Weisberg et al, 1998). We investigated whether or not the MTHFR gene polymorphisms is associated with pancreatic cancer by performing a meta-analysis
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