Abstract
Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms have been reported to be associated with pancreatic cancer, but the published studies have yielded inconsistent results. This study assessed the relationship between MTHFR gene polymorphisms and the risk for pancreatic cancer using a meta-analysis approach. A search of Google scholar, PubMed, Cochrane Library and CNKI databases before April 2012 was performed, and then associations of the MTHFR polymorphisms with pancreatic cancer risk were summarized. The association was assessed by odds ratios (ORs) with 95% confidence intervals (CIs). Publication bias was also calculated. Four relative studies on MTHFR gene polymorphisms (C667T and A1298C) were included in this meta-analysis. Overall, C667T (TT vs. CC:OR=1.61,95%CI=0.78-3.34; TT vs. CT: OR=1.41,95%CI=0.88-2.25; Dominant model:OR=0.68,95%CI=0.40-1.17; Recessive model: OR=0.82,95%CI=0.52-1.30) and A1298C (CC vs. AA:OR=1.01,95%CI=0.47-2.17; CC vs. AC: OR=0.99,95%CI=0.46-2.14; Dominant model:OR=1.01, 95%CI=0.47-2.20; Recessive model: OR=1.01,95%CI=0.80-1.26) did not increase pancreatic cancer risk. This meta-analysis indicated that MTHFR polymorphisms (C667T and A1298C) are not associated with pancreatic cancer risk.
Highlights
Pancreatic cancer is the tenth most common cause of cancer in the United States and is apparently the fourth leading cause of cancer mortality, it is estimated that 44030 new cases and 37660 associated deaths of the pancreatic cancer in 2011 (National Cancer Institute, 2012)
We investigated whether or not the Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms is associated with pancreatic cancer by performing a meta-analysis
The following criteria were used to include published studies: (1) case-control studies were included to evaluate the association between MTHFR polymorphism and pancreatic cancer risk; (2) sufficient genotype data were presented to calculate the odds ratios (ORs) and 95% confidence intervals (CIs); (3) Genotype distribution of the pancreatic cancer patients and the controls must be in Hardy-Weinberg equilibrium (HWE)
Summary
Pancreatic cancer is the tenth most common cause of cancer in the United States and is apparently the fourth leading cause of cancer mortality, it is estimated that 44030 new cases and 37660 associated deaths of the pancreatic cancer in 2011 (National Cancer Institute, 2012). This study assessed the relationship between MTHFR gene polymorphisms and the risk for pancreatic cancer using a meta-analysis approach. Results: Four relative studies on MTHFR gene polymorphisms (C667T and A1298C) were included in this meta-analysis.
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