Abstract
This hospital-based case–control study examined whether polymorphic DNA repair genes: XRCC1 Arg399 Gln, XRCC3 Thr241 Met and XPD Lys751 Gln, play a role in the susceptibility to colorectal cancer. We genotyped these polymorphisms for 727 newly diagnosed colorectal adenocarcinoma cases and 736 age and sex matched healthy controls in Taiwan. Although the colorectal cancer risk was not significantly associated with these genes, the risk was significantly elevated in younger subjects (≤60 years) with the XRCC1 399 Arg/Arg genotype compared to those with XRCC1 399 Gln allele (OR=1.46, 95% CI=1.06–2.99, P=0.02). The stratified analysis showed that XRCC3 interacted with meat consumption ( P for interaction=0.02), but was limited to the low meat consumption (OR=2.34, 95% CI=1.28–4.29). Our results suggest that the XRCC1 Arg399 Gln polymorphism may contribute to the risk of early-onset colorectal cancer and the XRCC3 Thr241 Met polymorphism may modify the risk for meat-associated colorectal cancer.
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