Abstract
Although the potential of mRNA in therapies is seemingly endless, obtaining the quantities of synthetic mRNA needed for clinical treatment remains a bottleneck in large-scale manufacturing. Traditionally, purification of mRNA is achieved by a variety of methods – but what is the right method for your process? We sum up the pros and cons of five common methods in this <a class="fr-file" href="https://bioinsights.blob.core.windows.net/uploads/95a5f02cfa924aeda46aa19dddfb4cc2.pdf" rel="noopener noreferrer" target="_blank">poster</a>. <p class="focus-visible" data-focus-visible-added="">To find out more, you can read the full article <a class="" href="https://www.insights.bio/cell-and-gene-therapy-insights/journal/article/2090/Supporting-development-of-mRNA-based-therapies-by-addressing-large-scale-purification-challenges" rel="noopener noreferrer" target="_blank">here</a>. <p data-focus-visible-added="" class="focus-visible">. <div class="authors authors-lg"><div class="author"><div class="author-img"><img src="https://bioinsights.blob.core.windows.net/uploads/655963e4c61d413aa270348acd382612.png" data-image="1"></div><div class="author-det"><h3 class="author-name">Kelly Flook, PhD</h3><h5 class="author-title">Senior Product Manager, Purification, Bioproduction Division, Thermo Fisher Scientific</h5> Kelly Flook is Senior Product Manager for Purification products within the Bioproduction Division at Thermo Fisher Scientific. Kelly has a PhD in Polymer and Analytical Chemistry from the University of Durham, UK. During her 15 years at Thermo Fisher, Kelly has gained extensive experience in product development across all scales of chromatography and related biological workflows. Kelly has a strong expertise in bead technology and bio-separations. Drawing from a diverse technical background, in her current role Kelly is responsible for new product development and commercialization of solutions across the downstream workflow. </div></div></div>
Published Version
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