Abstract
Most microRNAs have a stronger inhibitory effect in estrogen receptor-negative than in estrogen receptor-positive breast cancers
Highlights
Recent studies have shown that the regulatory effect of microRNAs can be investigated by examining expression changes of their target genes
We compare the RE-scores in estrogen receptor (ER)+ and ER- samples to identify miRNAs that show different regulatory effects between these two breast cancer subtypes
Based on RE-score calculations, we compared the inhibitory effects of miRNAs on their targets between two breast cancer subtypes, ER+ and ER-. miRNAs that showed significantly different inhibitory effects were identified for five independent datasets
Summary
Recent studies have shown that the regulatory effect of microRNAs can be investigated by examining expression changes of their target genes. Strong links between cancer and miRNA deregulation have been suggested by recent studies [8,9]. It has been shown that aberrant expression of miRNAs contributes to carcinogenesis by promoting the expression of proto-oncogenes or by inhibiting the expression of tumor suppressor genes. Some recent studies suggest that expression profiles of miRNAs are informative for the classification of human cancers. Based on miRNA-expression profiles, Lu et al [13] reported the classification of 334 leukemia and solid cancers that agrees well with the developmental lineage and differentiation state of the tumors. MiRNAs are thought of as promising biomarkers for cancer diagnosis and prognosis
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