MRNA-directed cell-free myelin basic protein synthesis: No evidence of neuronal control

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The specific mRNA of myelin basic protein (MBP) was isolated from active myelinating rat brains. The isolated mRNA was able to direct the synthesis of immunochemically detectable MBP in a wheat-germ cell free protein synthesis system. There was, however, no evidence of neuronal translational control of the in vitro MBP synthesis kinetics found within the experimental parameters. The possibility of neuronal control of MBP gene expression is therefore postulated likely to be at the transcriptional level.