MP85-03 SEXUAL DYSFUNCTION IN MEN WITH PRE-DIABETES – RESULTS FROM A CROSS-SECTIONAL STUDY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Medical, Hormonal & Non-surgical Therapy II1 Apr 2018MP85-03 SEXUAL DYSFUNCTION IN MEN WITH PRE-DIABETES – RESULTS FROM A CROSS-SECTIONAL STUDY Luca Boeri, Paolo Capogrosso, Filippo Pederzoli, Eugenio Ventimiglia, Walter Cazzaniga, Francesco Chierigo, Nicola Frego, Edoardo Pozzi, Federico Dehò, Emanuele Montanari, Franco Gaboardi, Vincenzo Mirone, Francesco Montorsi, and Andrea Salonia Luca BoeriLuca Boeri More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Filippo PederzoliFilippo Pederzoli More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Walter CazzanigaWalter Cazzaniga More articles by this author , Francesco ChierigoFrancesco Chierigo More articles by this author , Nicola FregoNicola Frego More articles by this author , Edoardo PozziEdoardo Pozzi More articles by this author , Federico DehòFederico Dehò More articles by this author , Emanuele MontanariEmanuele Montanari More articles by this author , Franco GaboardiFranco Gaboardi More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.2863AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Erectile dysfunction (ED) is causally related to diabetes mellitus (DM) and can also be considered as a useful marker for many forthcoming cardiovascular diseases (CVDs). Prediabetes (pDM) is considered a risk factor for the further development of both DM and CVDs. The association between pDM and ED has been scantly analysed. We aimed to assess the association between pDM and sexual health in a cohort of Caucasian-European men seeking medical help for ED as their primary compliant. METHODS Demographic, clinical and laboratory data from 372 consecutive men were analysed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI; categorized 0 vs ≥1). Patients were invited to complete the IIEF-EF domain (then categorized according to Cappelleri's criteria). Men were defined as having pDM if they had: (i) fasting plasma glucose concentration between 100 and 125 mg/dL; (ii) 2-h plasma glucose concentration in the 75 g oral glucose tolerance test from 140 mg/dL to 199 mg/dL (American Diabetes Association 2015). Hypogonadism was defined as total testosterone (tT) <3 ng/ml. Descriptive statistics and logistic regression models tested the odds (OR, 95%CI) of severe ED (defined as IIEF-EF<11) after adjusting for age, BMI, CCI≥1, pDM, tT values and cigarette smoking status. RESULTS Overall, pDM was found in 86 (23.1%) patients. Men with pDM had lower tT (p=0.04), higher triglycerides (p=0.005) and higher total cholesterol values (p=0.02) than those without pDM. Hypogonadism was more frequently reported by pDM+ men than those pDM- (34.3% vs. 22.3%; p=0.046). IIEF-EF domain score was lower in pDM+ than in pDM- patients (12.7 vs. 16.2; p=0.02). A higher rate of CCI≥1 (p=0.03) and a higher rate of severe ED (47.7% vs. 30.8%; p=0.013) were found in pDM+ than in pDM- patients. Multivariable logistic regression analysis showed that age (OR 1.02, p=0.014) and pDM+ (OR 2.03, p=0.021) achieved independent predictor status for severe ED, after accounting for BMI, CCI≥1, hypogonadal status and cigarette smoking. CONCLUSIONS One-out of five men seeking medical help for new onset ED showed glucose levels suggestive for pDM status. Men with pDM reported worse hormonal and metabolic profiles, along with a greater risk of severe ED compared to those pDM-. This finding stigmatizes the clinical relevance of a detailed metabolic and hormonal investigation in patients presenting with ED. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e1170 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Filippo Pederzoli More articles by this author Eugenio Ventimiglia More articles by this author Walter Cazzaniga More articles by this author Francesco Chierigo More articles by this author Nicola Frego More articles by this author Edoardo Pozzi More articles by this author Federico Dehò More articles by this author Emanuele Montanari More articles by this author Franco Gaboardi More articles by this author Vincenzo Mirone More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...