248 Sexual dysfunction in men with pre-diabetes – results from a cross-sectional study

Abstract

Erectile dysfunction (ED) is causally related to diabetes mellitus (DM) and can also be considered as a useful marker for many forthcoming cardiovascular diseases (CVDs). Prediabetes (pDM) is considered a risk factor for the further development of both DM and CVDs. The association between pDM and ED has been scantly analysed. We aimed to assess the association between pDM and sexual health in a cohort of men seeking medical help for ED as their primary compliant. Data from 372 men were analysed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients completed the IIEF-EF domain (categorized according to Cappelleri’s criteria). Men were defined as having pDM if they had: (i) fasting plasma glucose concentration between 100 and 125 mg/dL; (ii) 2-h plasma glucose concentration in the 75 g oral glucose tolerance test from 140 mg/dL to 199 mg/dL (American Diabetes Association 2015). Hypogonadism was defined as total testosterone (tT) <3 ng/ml. Descriptive statistics and logistic regression models tested the odds (OR, 95%CI) of severe ED (IIEF-EF<11) after adjusting for age, BMI, CCI≥1, pDM, tT values and cigarette smoking status.