MP8-03 OPTICAL DIAGNOSIS OF LOWER URINARY TRACT INFECTION: A PILOT STUDY IN CHILDREN.

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You have accessJournal of UrologyInfections/Inflammation of the Genitourinary Tract: Kidney & Bladder1 Apr 2014MP8-03 OPTICAL DIAGNOSIS OF LOWER URINARY TRACT INFECTION: A PILOT STUDY IN CHILDREN. Babak Shadgan, A.M. Kajbafzadeh, Lynn Stothers, Macnab Andrew, and Mark Nigro Babak ShadganBabak Shadgan More articles by this author , A.M. KajbafzadehA.M. Kajbafzadeh More articles by this author , Lynn StothersLynn Stothers More articles by this author , Macnab AndrewMacnab Andrew More articles by this author , and Mark NigroMark Nigro More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.346AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Lower urinary tract infection (LUTI) is a common and important urological condition that requires early diagnosis and treatment. Diagnosis is based on history and clinical symptoms confirmed by positive urine culture, which although feasible for the general population, it is not readily applicable in young children and individuals with neurogenic bladder where a reliable history and changes in sensation are lacking. As UTI-induced bladder inflammation is associated with an increase in perfusion and oxygen consumption, an optical method akin to oximetry capable of detecting changes in bladder oxygenation could provide early detection of LUTI. OBJECTIVE To determine if monitoring bladder oxygenation as a measure of bladder mucosal inflammation using transcutaneous near-infrared spectroscopy (NIRS) allows detection of the presence or absence of LUTI in children. METHODS A convenience sample of children referred to a pediatric urology clinic with an acute LUTI, and a control group, were studied. Diagnosis was confirmed by history, physical examination, laboratory investigations and culture. Participants had transcutaneous measurement of an absolute measure of tissue oxygen saturation (TSI%) in their bladder wall, and a quadriceps muscle control site, using a wireless NIRS device. RESULTS Thirty-four patients met the inclusion criteria (LUTI n=12 and controls n=22). Comparing LUTI to controls B.TSI% and TSI.diff values were significantly higher in the LUTI group (p<0.0001), while Q.TSI% values were not significantly different. CONCLUSIONS NIRS optical monitoring of an absolute measure of bladder wall oxygenation (TSI%) may offer a means of screening for LUTI where history and/or clinical signs are not available or adequate. Non UTI Group UTI Group Significance Q.TSI% Mean 67.9 70.4 P=0.20 SD (+ -) 6.5 5.4 Range 56.2-78.9 60.7-75.6 B.TSI% Mean 66.8 80.8 p=< 0.0001 SD (+ -) 7.3 5.9 Range 49.1-77.1 70.5-89.9 TSI diff Mean -1.1 10.4 P< 0.0001 SD (+ -) 3 3.9 Range -5.8-2.6 5.2-16.7 © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e75 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Babak Shadgan More articles by this author A.M. Kajbafzadeh More articles by this author Lynn Stothers More articles by this author Macnab Andrew More articles by this author Mark Nigro More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...