MP67-04 EVALUATION OF THE DE RITIS (ASPARTATE TRANSAMINASE/ALANINE TRANSAMINASE) RATIO AS A PREDICTOR OF ONCOLOGICAL OUTCOMES IN PATIENTS WITH UPPER URINARY TRACT UROTHELIAL CARCINOMA AFTER SURGERY

Abstract

You have accessJournal of UrologyKidney Cancer: Epidemiology & Evaluation/Staging II1 Apr 2017MP67-04 EVALUATION OF THE DE RITIS (ASPARTATE TRANSAMINASE/ALANINE TRANSAMINASE) RATIO AS A PREDICTOR OF ONCOLOGICAL OUTCOMES IN PATIENTS WITH UPPER URINARY TRACT UROTHELIAL CARCINOMA AFTER SURGERY Eu Chang Hwang, Yang Hyun Cho, Ho Seok Chung, Seung Il Jung, Taek Won Kang, Dong Deuk Kwon, Myung Ki Kim, Sung Gu Kang, Jun Cheon, Ja Yoon Ku, Hong Koo Ha, Chang Wook Jeong, Ja Hyeon Ku, Cheol Kwak, Tae Gyun Kwon, Tae-Hwan Kim, and Seock Hwan Choi Eu Chang HwangEu Chang Hwang More articles by this author , Yang Hyun ChoYang Hyun Cho More articles by this author , Ho Seok ChungHo Seok Chung More articles by this author , Seung Il JungSeung Il Jung More articles by this author , Taek Won KangTaek Won Kang More articles by this author , Dong Deuk KwonDong Deuk Kwon More articles by this author , Myung Ki KimMyung Ki Kim More articles by this author , Sung Gu KangSung Gu Kang More articles by this author , Jun CheonJun Cheon More articles by this author , Ja Yoon KuJa Yoon Ku More articles by this author , Hong Koo HaHong Koo Ha More articles by this author , Chang Wook JeongChang Wook Jeong More articles by this author , Ja Hyeon KuJa Hyeon Ku More articles by this author , Cheol KwakCheol Kwak More articles by this author , Tae Gyun KwonTae Gyun Kwon More articles by this author , Tae-Hwan KimTae-Hwan Kim More articles by this author , and Seock Hwan ChoiSeock Hwan Choi More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2040AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recently, several studies have shown that the De Ritis (aspartate transaminase/alanine transaminase) ratio can be a useful prognostic biomarker in patients with certain types of malignant tumors. However, the prognostic value of the De Ritis ratio in patients with upper tract urothelial carcinoma remains largely unknown. The aim of the present study was to evaluate the prognostic significance of the De Ritis ratio in patients with upper urinary tract urothelial carcinoma after radical nephroureterectomy (RNU). METHODS One thousand forty-nine patients who underwent RNU at eight institutions from 2004 to 2015 were retrospectively reviewed. The effect of the De Ritis ratio and conventional clinicopathological parameters were analyzed. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Multivariable analysis was performed using the Cox proportional hazard regression model. Cutoff values of the De Ritis ratio were calculated using a receiver operating characteristic curve (ROC). RESULTS According to the ROC curve, the cutoff value for overall death was 1.6 (p=0.002). The cancer-specific survival (CSS) and overall survival (OS) were significantly shorter for patients with a high De Ritis ratio (>1.6). Results of multivariable analysis identified an increased De Ritis ratio (>1.6) as independently related to worse CSS (hazard ratio [HR] 2.49, 95% confidence interval [CI] 1.70-3.64; p=0.001) and OS (HR 1.84, 95% CI 1.34-2.52; p=0.001). CONCLUSIONS Our results suggest that the De Ritis ratio can be a significant predictor of oncological outcomes in patients with upper urinary tract urothelial carcinoma after surgery. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e872 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Eu Chang Hwang More articles by this author Yang Hyun Cho More articles by this author Ho Seok Chung More articles by this author Seung Il Jung More articles by this author Taek Won Kang More articles by this author Dong Deuk Kwon More articles by this author Myung Ki Kim More articles by this author Sung Gu Kang More articles by this author Jun Cheon More articles by this author Ja Yoon Ku More articles by this author Hong Koo Ha More articles by this author Chang Wook Jeong More articles by this author Ja Hyeon Ku More articles by this author Cheol Kwak More articles by this author Tae Gyun Kwon More articles by this author Tae-Hwan Kim More articles by this author Seock Hwan Choi More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...