MP59-04 SYSTEMIC VASCULAR FUNCTION OF KIDNEY DONOR INFLUENCES SHORT-TERM RENAL PERFORMANCE OF RECEPTOR

Abstract

Listen

Translate article

INTRODUCTION AND OBJECTIVE: Renal function is highly dependent on adequate vascular function. This is especially relevant when considering the increasing use of older and marginal kidney donors to overcome organ unavailability. Our aim was to evaluate the influence of donor’s vascular function at different vascular beds on renal function in kidney recipients. METHODS: Aorta, mesenteric microvessels (MM) and corpus cavernosum (CC) specimens were obtained at the time of kidney explant for transplantation and vascular function was ex vivo determined by evaluating adrenergic contractions to norepinephrine and endothelium-dependent vasodilations to bradykinin (BK, MM) or acetylcholine (ACh, CC). RESULTS: Vascular function in each donor (n=38) was correlated with serum creatinine levels (SC) and glomerular filtration rate (GFR) in each receptor(s) (n=49). Endothelium-dependent vasodilation of donor MM (pEC50 for BK) was significantly and negatively associated with SC (r2=0.245, p=0.003) while positively with GFR (r2=0.267, p=0.002) at 3 months after transplantation but significance was lost at 6 months (SC: r2=0.114, p=0.092; GFR: r2=0.131, p=0.069). Receptor’s GFR was also positively associated with endothelium-dependent relaxation (pEC50 for ACh) in CC from male donors (r2=0.310;p=0.006) and negatively with adrenergic contraction in aorta (r2=0.289, p=0.001) at 3 months. These associations were also lost at 6 months after transplantation. Moreover, receptors with GFR≥60 ml/min at 3 months received the kidney from donors displaying a significantly better endothelial vasodilation in MM (pEC50 for BK 7.60±0.25 vs. 6.71±0.15, p=0.004). Conversely, donors in the highest tertile of endothelium-dependent relaxation in MM or CC displayed lower SC and higher GFR at 3 and 6 months after transplantation. CONCLUSIONS: Systemic vascular function of kidney donor is a determinant for renal function in the receptor at short-term but the influence of receptor condition on renal performance probably prevails at later time. Source of Funding: No