MP56-05 IMPACT OF COMPREHENSIVE MEASUREMENT OF SURGICAL OUTCOMES ON SUBJECTIVE ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE IN PATIENTS RECEIVING RADICAL CYSTECTOMY WITH ORTHOTOPIC PADUA ILEAL BLADDER: SINGLE CENTER RANDOMIZED CONTROLLED TRIAL

Abstract

You have accessJournal of UrologyCME1 May 2022MP56-05 IMPACT OF COMPREHENSIVE MEASUREMENT OF SURGICAL OUTCOMES ON SUBJECTIVE ASSESSMENT OF HEALTH RELATED QUALITY OF LIFE IN PATIENTS RECEIVING RADICAL CYSTECTOMY WITH ORTHOTOPIC PADUA ILEAL BLADDER: SINGLE CENTER RANDOMIZED CONTROLLED TRIAL Riccardo Mastroianni, Gabriele Tuderti, Umberto Anceschi, Alfredo Maria Bove, Leonardo Misuraca, Aldo Brassetti, Mariaconsiglia Ferriero, Salvatore Guaglianone, Michele Gallucci, and Giuseppe Simone Riccardo MastroianniRiccardo Mastroianni More articles by this author , Gabriele TudertiGabriele Tuderti More articles by this author , Umberto AnceschiUmberto Anceschi More articles by this author , Alfredo Maria BoveAlfredo Maria Bove More articles by this author , Leonardo MisuracaLeonardo Misuraca More articles by this author , Aldo BrassettiAldo Brassetti More articles by this author , Mariaconsiglia FerrieroMariaconsiglia Ferriero More articles by this author , Salvatore GuaglianoneSalvatore Guaglianone More articles by this author , Michele GallucciMichele Gallucci More articles by this author , and Giuseppe SimoneGiuseppe Simone More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002639.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Functional outcomes of Radical Cystectomy (RC) with orthotopic padua ileal bladder (PIB) are poorly reported and their impact on HRQoL underivestigated. We evaluated impact of trifecta and tetrafecta achievement on global health status from an ongoing RCT (NCT03434132). METHODS: Inclusion criteria were: diagnostic TURBt with cT2-4cN0cM0, or recurrent HG NMIBC and no anesthesiologic contraindications to RARC. Between Jan 2018 and Sept 2020 patients were enrolled with a covariate adaptive randomization process based on BMI, ASA, baseline hgb, UD, neoadjuvant chemo and cTstage. We previously described Trifecta as the combination of day continence, no major complication (CD ≥3) and recurrence-free status, at 1yr. Tetrafecta also included night continence. Global health status/QoL (QL) was evaluated from EORTC QLQC30 questionnaires. Satisfactory HRQoL outcome was defined as 1yr QL decrease <10% from baseline. Continuous and categorical variables were compared using Student t and Chi-Square tests. Logistic regression analysis was performed to assess the role of trifecta achievement on HRQoL. RESULTS: Out of 116 patients enrolled 88 underwent PIB and 75 reached a minimum follow-up of 1yr. Baseline clinical features were reported Table 1. Trifecta was achieved in 41 patients (55%) while tetrafecta in 17 (23%). Trifecta achievement had a significant impact on QL patients who achieved trifecta had a lower probability (34%) to observe a QL decrease≥10% compared with patients who did not achieve trifecta (62%) (p=0.021). Tetrafecta achievement had a negligible impact on QL (29% and 52%, tetrafecta achieved vs tetrafecta not achieved p=0.166) suggesting a minor impact of night continence on HRQoL (Figure 1). At logistic regression analysis patients who achieved trifecta had 68% lower probability to experience an overall QL decrease ≥10% (OR 0.321, 95% CI 0.125-0.827; p=0.019). CONCLUSIONS: This study described a significant impact of trifecta on HRQoL, providing a strict correlation between objective evaluation of surgical outcomes and self reported HRQoL. Tetrafecta seems to play a negligible role on HRQoL, even if a larger cohort is needed to establish the HRQoL impact of night urinary continence. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e972 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Riccardo Mastroianni More articles by this author Gabriele Tuderti More articles by this author Umberto Anceschi More articles by this author Alfredo Maria Bove More articles by this author Leonardo Misuraca More articles by this author Aldo Brassetti More articles by this author Mariaconsiglia Ferriero More articles by this author Salvatore Guaglianone More articles by this author Michele Gallucci More articles by this author Giuseppe Simone More articles by this author Expand All Advertisement PDF DownloadLoading ...