PD10-08 THE IMPACT OF BASELINE HEALTH-RELATED QUALITY OF LIFE ON BLADDER-CANCER-SPECIFIC SURVIVAL IN PATIENTS TREATED WITH RADICAL CYSTECTOMY

Abstract

You have accessJournal of UrologyCME1 May 2022PD10-08 THE IMPACT OF BASELINE HEALTH-RELATED QUALITY OF LIFE ON BLADDER-CANCER-SPECIFIC SURVIVAL IN PATIENTS TREATED WITH RADICAL CYSTECTOMY Thilo Westhofen, Lennert Eismann, Alexander Buchner, Boris Schlenker, Clemens Gießen-Jung, Armin Becker, Christian G. Stief, and Alexander Kretschmer Thilo WesthofenThilo Westhofen More articles by this author , Lennert EismannLennert Eismann More articles by this author , Alexander BuchnerAlexander Buchner More articles by this author , Boris SchlenkerBoris Schlenker More articles by this author , Clemens Gießen-JungClemens Gießen-Jung More articles by this author , Armin BeckerArmin Becker More articles by this author , Christian G. StiefChristian G. Stief More articles by this author , and Alexander KretschmerAlexander Kretschmer More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002536.08AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Previous studies have shown that baseline health-related quality of life (HRQOL) is a valuable prognostic indicator of survival outcomes for various cancer entities in the metastatic setting, yet there is no evidence on the prognostic value of baseline HRQOL for patients undergoing radical cystectomy (RC) with curative intent. The goal of this study was to evaluate the influence of baseline preoperative HRQOL on cancer specific survival prognosis for patients undergoing RC. METHODS: 407 patients with prospectively assessed baseline HRQOL prior RC were included. Patients were stratified by the global health status (GHS) domain of the EORTC QLQ-C30 questionnaire, and good general HRQOL was defined as GHS ≥70 based on validated cut-off levels. A 1:2 propensity-score-matched analysis of n=357 patients [n=125 (GHS ≥70), n=232 (GHS <70)] was performed. Primary endpoint was cancer-specific survival (CSS), secondary endpoints encompassed overall survival (OS) and recurrence-free survival (RFS). Multivariate Cox regression models were performed to assess prognostic significance of baseline GHS on survival outcomes. RESULTS: Median follow-up was 40.5mo. Patients subcohorts were well-balanced. All baseline QLQ-C30 functioning scales were in favour of the GHS≥70 cohort (each p <0.001). 5-yr CSS (82% vs. 65%; p=0.001), 5-yr OS (76% vs 53%; p=0.001) and 5-yr-RFS (50% vs. 39%; p=0.04) and were significantly increased in the GHS ≥70 cohort. GHS≥70 was confirmed as an independent predictor for increased CSS (HR 0.43, 95%CI 0.21–0.89; p=0.028), OS (HR 0.56, 95%CI 0.31–0.90; p=0.031) and RFS (HR 0.52, 95%CI 0.31–0.87; p=0.013) multivariate analysis. CONCLUSIONS: Our findings suggest preoperative baseline HRQOL to have a pronounced predictive value for patients undergoing RC with curative intent for bladder cancer. We found baseline good general HRQOL to accurately predict increased CSS, OS and RFS. Source of Funding: none © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e186 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Thilo Westhofen More articles by this author Lennert Eismann More articles by this author Alexander Buchner More articles by this author Boris Schlenker More articles by this author Clemens Gießen-Jung More articles by this author Armin Becker More articles by this author Christian G. Stief More articles by this author Alexander Kretschmer More articles by this author Expand All Advertisement PDF DownloadLoading ...