MP53-02 EVALUATION OF GALLIUM-68 PSMA PET/CT IMAGING IN INDIVIDUALS WITH BIOCHEMICAL RECURRENCE FOLLOWING RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2018MP53-02 EVALUATION OF GALLIUM-68 PSMA PET/CT IMAGING IN INDIVIDUALS WITH BIOCHEMICAL RECURRENCE FOLLOWING RADICAL PROSTATECTOMY Chris Rothe, Yuigi Yuminaga, Jonathan Kam, Kieran Beattie, Mohan Arianayagam, Bertram Canagasingham, Richard Ferguson, Mohamed Khadra, Raymond Ko, Ken Le, Sunny Nalavenkata, Celi Varol, and Matthew Winter Chris RotheChris Rothe More articles by this author , Yuigi YuminagaYuigi Yuminaga More articles by this author , Jonathan KamJonathan Kam More articles by this author , Kieran BeattieKieran Beattie More articles by this author , Mohan ArianayagamMohan Arianayagam More articles by this author , Bertram CanagasinghamBertram Canagasingham More articles by this author , Richard FergusonRichard Ferguson More articles by this author , Mohamed KhadraMohamed Khadra More articles by this author , Raymond KoRaymond Ko More articles by this author , Ken LeKen Le More articles by this author , Sunny NalavenkataSunny Nalavenkata More articles by this author , Celi VarolCeli Varol More articles by this author , and Matthew WinterMatthew Winter More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1673AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Prostate specific membrane antigen (PSMA) is a transmembrane protein that is highly expressed in most prostate cancers, thus presenting a unique imaging target for the detection of prostate cancer recurrence. This study aimed to investigate the correlation between prostate specific antigen (PSA) level and positive findings on the Ga-68 PSMA PET/CT (PSMA PET) scan in patients with biochemical recurrence following radical prostatectomy. METHODS We conducted a chart review of our institutional prospective database to identify patients with post-prostatectomy biochemical recurrence who underwent 68Ga-PSMA PET/CT (PSMA PET). We then analysed the probability of a positive scan finding for PSMA avid prostate cancer recurrence to the PSA level. RESULTS A total of 391 patients were identified for analysis. The median PSA of all individuals included in the study was 2.05ng/ml. Please refer to table 1 and 2. CONCLUSIONS The probability of PSMA avid lesions detected on a Ga-68 PSMA PET/CT are correlated to the PSA levels in post-prostatectomy patients with biochemical recurrence. Even at low PSA levels (<0.2ng/ml) there is a 42% probability of detecting a PSMA avid lesion, this increases to greater than 90% when PSA levels are >2.0ng/ml. Further studies are required to investigate how detection of PSMA avid lesions will influence the management of these patients with early disease recurrence. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e704-e705 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Chris Rothe More articles by this author Yuigi Yuminaga More articles by this author Jonathan Kam More articles by this author Kieran Beattie More articles by this author Mohan Arianayagam More articles by this author Bertram Canagasingham More articles by this author Richard Ferguson More articles by this author Mohamed Khadra More articles by this author Raymond Ko More articles by this author Ken Le More articles by this author Sunny Nalavenkata More articles by this author Celi Varol More articles by this author Matthew Winter More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...