MP52-20 THE IMPACT OF LOWER URINARY TRACT SYMPTOMS (LUTS) ON DEPRESSION AND DEPRESSIVE SYMPTOMS AMONG WOMEN 20-69 YEARS

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Female Incontinence: Therapy II (MP52)1 Sep 2021MP52-20 THE IMPACT OF LOWER URINARY TRACT SYMPTOMS (LUTS) ON DEPRESSION AND DEPRESSIVE SYMPTOMS AMONG WOMEN 20-69 YEARS Stephanie Gleicher, Timothy Byler, and Natasha Ginzburg Stephanie GleicherStephanie Gleicher More articles by this author , Timothy BylerTimothy Byler More articles by this author , and Natasha GinzburgNatasha Ginzburg More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002082.20AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Studies have shown that women with LUTS have higher rates of depression, anxiety, and overall worse health perception. Correlations have been shown between symptom severity and worsened mental health status. The aim of this study was to compare the impact of varying urinary symptoms, such as SUI, UUI, and nocturia, on depression and depressive symptoms among women aged 20-69 years. METHODS: We queried NHANES between 2013-2018 for women aged 20-69 years. We defined SUI as “leakage during physical activity”, UUI as “leakage during non-physical activity” and nocturia as “≥ 2 voids/night”. Depression was defined by DSM criteria with cases reporting ≥5 symptoms from the patient health questionnaire (PHQ9) depression screening tool. We assessed various demographic and clinical variables such as age, race, education, insurance status, smoking status, hypertension (HTN), hyperlipidemia (HLD), body mass index (BMI), hemoglobin A1c (HbA1c), perceived heath status, and visits to mental health providers. We performed univariate analysis and multivariable logistic regression. RESULTS: Of the 6284 participants, 27% reported nocturia, 42% had SUI, and 9% had UUI. Depression was found in 5% of the cohort. Women with depression were significantly less educated, had less health insurance, more commonly smoked, had HTN and HLD, had higher BMI, and had higher HbA1c. Depressed women were twice as likely to have nocturia (51% vs 26%, p<0.001). 64% of depressed women had SUI and 21% had UUI (p<0.001). Depressed women were three times more likely to have negative health perception (36% vs 9%, p<0.001). Multivariate regression revealed increased risk of depression among women with SUI (OR 1.79, p=0.004) and nocturia (OR 1.65, p=0.007), but not UUI. While evaluating the impact of specific PHQ9 elements and SUI, multivariate analysis revealed significant correlations with “feeling tired” (OR 1.26) and suicidal ideation (OR 1.77). Nocturia and depression were significantly correlated with decreased interest (OR 1.39), poor sleep (OR 1.71), “feeling tired” (OR 1.26) and changes in appetite (OR 1.37). CONCLUSIONS: SUI and nocturia appear to be significantly associated with depression and depressive symptoms. These findings reinforce that LUTS cannot be considered an isolated symptom, but a factor impacting overall mental-health wellbeing. Source of Funding: N/A © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e938-e938 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Stephanie Gleicher More articles by this author Timothy Byler More articles by this author Natasha Ginzburg More articles by this author Expand All Advertisement Loading ...