MP48-01 THE N-GLYCAN SIGNATURE OF SERUM IMMUNOGLOBULINS IS A DIAGNOSTIC BIOMARKER OF UROTHELIAL CARCINOMAS

Abstract

You have accessJournal of UrologyBladder Cancer: Upper Tract Transitional Cell Carcinoma II (MP48)1 Sep 2021MP48-01 THE N-GLYCAN SIGNATURE OF SERUM IMMUNOGLOBULINS IS A DIAGNOSTIC BIOMARKER OF UROTHELIAL CARCINOMAS Hirotake Kodama, Tohru Yoneyama, Takuma Narita, Yuta Kojima, Hiromichi Iwamura, Teppei Okamoto, Hayato Yamamoto, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, and Chikara Ohyama Hirotake KodamaHirotake Kodama More articles by this author , Tohru YoneyamaTohru Yoneyama More articles by this author , Takuma NaritaTakuma Narita More articles by this author , Yuta KojimaYuta Kojima More articles by this author , Hiromichi IwamuraHiromichi Iwamura More articles by this author , Teppei OkamotoTeppei Okamoto More articles by this author , Hayato YamamotoHayato Yamamoto More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002074.01AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Discriminating between urothelial carcinoma (UC) including bladder cancer (BCa) and upper urinary tract UC (UTUC) is often challenging. METHODS: We evaluated the diagnostic performance of BCa and UTUC discrimination scores that we developed based on N-glycosylation signatures of immunoglobulins (Igs) for the detection of UC including BCa and UTUC. The N-glycosylation signatures of Igs from serum samples of in 405 patients with UC (176 with BCa, 104 with UTUC), 21 with urinary tract infection, and 104 healthy volunteers were measured retrospectively using automated capillary-electrophoresis-based N-glycomics analysis. The UTUC or BCa discriminating scores were established by discriminant analysis using the N-glycan signatures of Igs. Diagnostic performance was evaluated using the area under receiver operating characteristics curve (AUC) and decision curve analyses (DCA). RESULTS: The BCa score for discriminating BCa (AUC: 0.979) and UTUC score for discriminating UTUC (AUC: 0.831) provided significantly better clinical performance than urine cytology negative or gross hematuria negative or clinical T1 cases. The DCA analysis revealed that adding the BCa and UTUC scores to gross hematuria status avoided the need for more intervention without missing UC (risk threshold: 8%–95%). We found that a UC diagnostic nomogram based on the combination of gross hematuria, UTUC score and BCa score could detect UC with an AUC of 0.939, positive predictive value of 91.8%, and negative predictive value of 75.7%. CONCLUSIONS: The UC score based on N-glycosylation signatures of Igs is a promising approach for the diagnosis of UC. Source of Funding: none © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e862-e863 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Hirotake Kodama More articles by this author Tohru Yoneyama More articles by this author Takuma Narita More articles by this author Yuta Kojima More articles by this author Hiromichi Iwamura More articles by this author Teppei Okamoto More articles by this author Hayato Yamamoto More articles by this author Shingo Hatakeyama More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement Loading ...