MP47-13 AN UNACKNOWLEDGED CLINICAL DEPRESSION IS HIGHLY PREVALENT IN TESTOSTERONE DEFICIENT CAUCASIAN-EUROPEAN MEN SEEKING MEDICAL HELP FOR SEXUAL DYSFUNCTION

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Evaluation1 Apr 2016MP47-13 AN UNACKNOWLEDGED CLINICAL DEPRESSION IS HIGHLY PREVALENT IN TESTOSTERONE DEFICIENT CAUCASIAN-EUROPEAN MEN SEEKING MEDICAL HELP FOR SEXUAL DYSFUNCTION Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Giovanni La Croce, Roberta Scano, Donatella Moretti, Federico Dehò, Alberto Briganti, Vincenzo Mirone, Francesco Montorsi, and Andrea Salonia Luca BoeriLuca Boeri More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Giovanni La CroceGiovanni La Croce More articles by this author , Roberta ScanoRoberta Scano More articles by this author , Donatella MorettiDonatella Moretti More articles by this author , Federico DehòFederico Dehò More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.332AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Large studies examining the relationship between testosterone levels and depressive symptoms (DS) have shown conflicting results. We investigated the association between testosterone levels (tT) and mood impairment in a homogeneous cohort of Caucasian-European men seeking medical help for either solitary erectile dysfunction (ED) or premature ejaculation (PE) as primary reasons for office evaluation, without any known psychiatric disorders. METHODS Complete data from the last 224 consecutive patients aged 18-70 years were analysed. Patients completed the 21-item Beck's inventory for Depression (BDI), the International Index of Erectile Function (IIEF) and the Premature Ejaculation Diagnostic Tool (PEDT). DS were considered for BDI≥11. Clinical depression (CD) was defined as a BDI ≥16. IIEF-EF was categorized according to Cappelleri's criteria. Testosterone deficiency (TD) was defined as tT <3.5 ng/mL. Patients were categorized according to their PEDT score (PEDT <11 vs. ≥11). Comorbidities were scored with the Charlson Comorbidity Index (CCI, categorized 0 vs ≥1). Descriptive statistics and logistic regression models tested the association between tT and DS and/or CD. RESULTS Overall, mean (SD) age was 45.7 (14.1) yrs. Mean tT value and BDI were 4.7 (2.4) ng/mL and 8.59 (7.9), respectively. According to IIEF-EF domain scores, 37 (16.5%), 21 (9.4%), 33 (14.7%) and 71 (31.7%) men reported mild, mild-to-moderate, moderate and severe ED, respectively. Solitary PE was complained by 62 (27.6%) patients. Of all, obesity (NIH class≥1) and TD were observed 31 (14%) and in 86 (38.4%) patients, respectively. BDI scores suggestive for DS and CD were observed in 64 (28.6%) and 41 (18.3%) patients, respectively. Patients with TD showed higher rate of obesity (23.5% vs. 8.0%; p<0.001), BDI scores suggestive for either DS (41.9% vs. 20.3%; p=0.001) or CD (27.9% vs. 12.3%; p=0.003) compared to eugonadal patients. No differences in terms of age, CCI, IIEF-EF and PEDT were observed between the two groups. At univariate analysis tT was negatively correlated BDI scores (Rho -0.23; p<0.001). At multivariate analysis, both BMI (OR 1.1; p=0.013) and TD (OR 2.1; p=0.03) achieved independent predictor status for DS, after accounting for age, CCI, IIEF-EF and PEDT. Conversely, only TD (OR 2.34; p=0.03) achieved independent predictor status for CD. CONCLUSIONS These findings showed that both DS and unacknowledged CD are highly prevalent in men with concomitant TD and sexual dysfunction. Testosterone deficiency emerged as an independent predictor for CD in this cohort of patients without known psychiatric disorders. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e631 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Eugenio Ventimiglia More articles by this author Giovanni La Croce More articles by this author Roberta Scano More articles by this author Donatella Moretti More articles by this author Federico Dehò More articles by this author Alberto Briganti More articles by this author Vincenzo Mirone More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...