PO-01-016 Premature ejaculation is not associated with prediabetes in men seeking medical help for sexual dysfunction: Findings from a cross-sectional study

Abstract

Assess rates of premature ejaculation (PE) in men with normo-glycemia, diabetes mellitus (DM) and prediabetes (PreDM) seeking first medical help for sexual dysfunction. .Data from 323 men were analyzed. Patients completed the International Index of Erectile Function- Erectile function (IIEF-EF) domain and the Premature Ejaculation Diagnostic Tool (PEDT). PE was defined as PEDT ≥ 11. DM was detected through a detailed medical history. Men were defined as having PreDM according to the criteria defined by the American Diabetes Association (2015). Descriptive statistics and logistic regression models tested the association between clinical predictors and PEDT scores. Primary reasons for office evaluation were erectile dysfunction (ED), PE and ED+PE in 178 (55.1%), 37 (11.4%) and 108 (33.4%) patients, respectively. Overall, 189 (58.5%), 78 (24.1%) and 56 (17.3%) men had normo-glycemia, PreDM and DM respectively. Men with PE were older (p=0.03) and had lower TSH values than those without PE (p=0.04). Patients with DM more frequently had PE than controls (58.9% vs. 39.2%; p<0.01), while similar rates of PE were found between men with PreDM and controls (37.4% vs. 39.2%; p=0.212). Similarly, mean PEDT score was significantly higher in DM men than controls (11.8 vs. 8.5; p<0.001). No difference in PEDT score was found between PreDM men and controls. At univariable logistic regression analysis, DM (OR 2.23, p=0.01), lower IIEF-EF score (OR 0.96, p<0.001) and lower TSH values (OR 0.71, p=0.021) were associated with PE. At multivariable logistic regression analysis only lower IIEF-EF score (OR 0.96, p=0.02) and TSH values (OR 0.69, p=0.02) depicted independent association with PE, after accounting for age, BMI, Charlson Comorbidity Index and glycemic status.