MP43-18 INCREASED PROSTATE CANCER UPGRADING RATE IS ASSOCIATED WITH POSITIVE FAMILY HISTORY IN CAUCASIANS BUT NOT IN AFRICAN AMERICANS

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening IV (MP43)1 Sep 2021MP43-18 INCREASED PROSTATE CANCER UPGRADING RATE IS ASSOCIATED WITH POSITIVE FAMILY HISTORY IN CAUCASIANS BUT NOT IN AFRICAN AMERICANS Aaron Bradshaw, Ram Pathak, Adam Cohen, Bridget Krol, Justin Refugia, Parth Thakker, Shuo Liu, and Ashok Hemal Aaron BradshawAaron Bradshaw More articles by this author , Ram PathakRam Pathak More articles by this author , Adam CohenAdam Cohen More articles by this author , Bridget KrolBridget Krol More articles by this author , Justin RefugiaJustin Refugia More articles by this author , Parth ThakkerParth Thakker More articles by this author , Shuo LiuShuo Liu More articles by this author , and Ashok HemalAshok Hemal More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002064.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: While the pathology and outcomes of prostate cancer (PCa) have been shown to differ between the Caucasian and African American (AA) population, the impact of family history has not yet been comparatively assessed between the two. We sought to separately evaluate the impact of family history on PCa outcomes in AA and Caucasian men. METHODS: We performed a retrospective analysis of consecutive AA with clinically localized PCa who underwent robotic radical prostatectomy (RRP). For comparison, we abstracted 250 consecutive Caucasian patients who also underwent RRP. The cohorts were further subdivided for analysis into those with or without a family history of PCa. Family history was classified as a first degree relative with PCa and was determined and recorded at time of diagnosis. Clinical and demographic variables were obtained via chart review and compared between those with or without family history of PCa. Primary outcomes were impact on post-operative PSA and rate of upgrading/upstaging for each race. RESULTS: A similar proportion of both Caucasian (65/250) and AA (63/246) groups were found to have significant family history of PCa. Within each cohort, there was no significant difference in median follow-up length, age, BMI, or prostate volume between positive or negative family history groups. At the time of diagnosis, mean PSA was lower in Caucasians with positive history (6.34 vs. 8.27, p=0.042) but not in AA (p=0.64). The distribution of disease risk was not significantly different between family history groups within either cohort. Pathologic upgrading and upstaging rates were also not significantly different based on family history, with exception for Caucasians where an increased rate of upgrading in those men with positive family history (31% vs. 17%, p=0.012). There was ultimately no difference in the first post-operative PSA. CONCLUSIONS: Positive family history does not appear to be associated with adverse oncologic outcomes in AA men, but is associated with increased risk of upgrading in Caucasians. Further study may help understand whether this is due to an intrinsic difference in disease biology or related to other aspects of screening, diagnosis, and treatment. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e789-e789 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Aaron Bradshaw More articles by this author Ram Pathak More articles by this author Adam Cohen More articles by this author Bridget Krol More articles by this author Justin Refugia More articles by this author Parth Thakker More articles by this author Shuo Liu More articles by this author Ashok Hemal More articles by this author Expand All Advertisement Loading ...