MP40-02 INCREASED UPTAKE OF RENAL TUMOUR BIOPSIES FOR SMALL RENAL MASSES – RESULTS OF A MULTICENTRE CANADIAN EXPERIENCE

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You have accessJournal of UrologyKidney Cancer; Evaluation/Staging IV1 Apr 2014MP40-02 INCREASED UPTAKE OF RENAL TUMOUR BIOPSIES FOR SMALL RENAL MASSES – RESULTS OF A MULTICENTRE CANADIAN EXPERIENCE Jaimin R. Bhatt, Simon Tanguay, Zhihui Liu, Patrick O. Richard, Anil Kapoor, Ricardo Rendon, Louis Lacombe, Peter Black, Stephen Pautler, Rodney Breau, Ronald Moore, Michael Jewett, and Antonio Finelli Jaimin R. BhattJaimin R. Bhatt More articles by this author , Simon TanguaySimon Tanguay More articles by this author , Zhihui LiuZhihui Liu More articles by this author , Patrick O. RichardPatrick O. Richard More articles by this author , Anil KapoorAnil Kapoor More articles by this author , Ricardo RendonRicardo Rendon More articles by this author , Louis LacombeLouis Lacombe More articles by this author , Peter BlackPeter Black More articles by this author , Stephen PautlerStephen Pautler More articles by this author , Rodney BreauRodney Breau More articles by this author , Ronald MooreRonald Moore More articles by this author , Michael JewettMichael Jewett More articles by this author , and Antonio FinelliAntonio Finelli More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1337AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives Renal tumour biopsy (RTB) has become increasingly important in the management of the small renal mass (SRM) especially over the last decade. We aim to evaluate the uptake of RTB across Canadian centres using the Canadian Kidney Cancer Information System (CKCis) - a centralised database of kidney tumour patients. Methods A review of the CKCis database on RTB recorded from 6 provinces across Canada was performed. The database was started in 2011 and preceding data has been entered retrospectively. We analyzed patient demographics, biopsy diagnostic rates, histological subtype, tumour grade specifically in clinical T1a tumours, and determined concordance rates compared with surgical pathology. Results Of 2927 patients and 882 biopsies recorded on the CKCis database, 616 were RTBs of 552 patients between 1994 and 2013. There was a significant increase in the uptake of renal tumour biopsies (15% in 2010, 22% in 2011 and 42% in 2013) when compared to overall new diagnoses. Left and right renal biopsies were roughly equal. Mean age was 64 years. There was a male preponderance of 65%. Ninety per cent had one biopsy, while 10% had 2 or more. Of 470 patients with a recorded clinical T-stage, 259 or 55% were cT1a tumours, with 45% biopsies performed for lesions > 4cm. For the cT1a sub-group of 259 patients, a diagnosis was available in 236 or 91%. Of these, a malignant diagnosis was made in 80.4% while 19.6% were benign. Histological subtype was available in 88% of diagnostic biopsies (208/236) with 190 malignant (117 conventional clear cell, 44 papillary and 29 chromophobe) and 18 benign (2 angiomyolipoma and 16 oncocytoma). Grade was available in 67% of malignant cases. Of 259 cT1a tumours, 116 underwent surgery with partial nephrectomy in 78% and radical nephrectomy in 22%. Of all lesions recorded with a final surgical pathology, there was a 100% malignancy concordance rate. Histological subtype concordance rates varied between 80-85%. Grade concordance was lower at 65%. Conclusions Our findings confirm an increased uptake of RTB in diagnosis of SRMs of <4cm over time with excellent diagnostic rates and overall malignancy concordance rates. There is however need to improve concordance rates for both grade and histological subtype as centres increase their uptake of renal tumour biopsies with the opportunity for enhanced experience and skills transfer. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e434 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Jaimin R. Bhatt More articles by this author Simon Tanguay More articles by this author Zhihui Liu More articles by this author Patrick O. Richard More articles by this author Anil Kapoor More articles by this author Ricardo Rendon More articles by this author Louis Lacombe More articles by this author Peter Black More articles by this author Stephen Pautler More articles by this author Rodney Breau More articles by this author Ronald Moore More articles by this author Michael Jewett More articles by this author Antonio Finelli More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...