MP4-01 SAFETY AND EFFICACY OF THE UROGUIDE, A NOVEL STRESS URINARY INCONTINENCE DEVICE IN THE FEMALE RODENT

Abstract

You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research II1 Apr 2014MP4-01 SAFETY AND EFFICACY OF THE UROGUIDE, A NOVEL STRESS URINARY INCONTINENCE DEVICE IN THE FEMALE RODENT Shida Li, Franklin Yao, Melissa A. Laudano, Daniel J. Lee, Fujun Zhao, Bilal Chughtai, and Richard K. Lee Shida LiShida Li More articles by this author , Franklin YaoFranklin Yao More articles by this author , Melissa A. LaudanoMelissa A. Laudano More articles by this author , Daniel J. LeeDaniel J. Lee More articles by this author , Fujun ZhaoFujun Zhao More articles by this author , Bilal ChughtaiBilal Chughtai More articles by this author , and Richard K. LeeRichard K. Lee More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.201AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Stress urinary incontinence (SUI) is a prevalent condition affecting women's health. The Uroguide is a novel suburethral implant that acts to redirect and disperse the biomechanical forces acting upon the urethra. The purpose of this study was to determine the effects of the Uroguide in restoring leak point pressure (LPP) in a rodent model for SUI. METHODS A total of 36 Sprague-Dawley retired female breeder rodents was randomly assigned to 4 groups: 1) control (n=5), 2) SUI only (n=5), 3) SUI+sham implant placement (n=5), and 4) SUI+Uroguide (n=20). SUI was induced through pudendal nerve transection after baseline LPP measurements. Cystometry was performed via suprapubic catheter implanted into the bladder of the rodents. LPP measurements were taken at baseline, 1, and 5 weeks. Uroguide implants were placed after week 1 LPP measurement. Statistical analysis was performed using the Kruskal-Wallis and Friedman tests. The study was funded by Urova Medical, Inc. RESULTS A total of 28 rodents survived the end of the study: control (n=5), SUI (n=2), SUI+sham implant placement (n=4), and SUI+Uroguide (n=17). Declines in the LPP were seen for all SUI animals at week 1 (Table 1, p=0.02). Uroguide implants were placed successfully with no evidence of infection or erosion. LPP was successfully restored in the Uroguide animal group (p=0.006) by week 5. CONCLUSIONS Implantation of the Uroguide appears to restore LPP in female SUI rodents. Future research is needed to verify its efficacy in larger animal groups and to further evaluate its safety and biocompatibility. Table 1. LPP measurements in cmH2O Control SUI only SUI+sham implant SUI+ Uroguide p-value Median LPPbaseline±IQR 54.0±20.6 44.2±0 50.6±18.8 46.0±14.4 0.32 Median LPP1week±IQR 38.4±14.0 22.7±0 22.1±12.1 22.2±4.8 0.02 Median LPP5week±IQR 48.0±12.7 31.1±0 18.5±17.8 45.8±10.9 0.006 © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e42 Peer Review Report Advertisement Copyright & Permissions© 2014MetricsAuthor Information Shida Li More articles by this author Franklin Yao More articles by this author Melissa A. Laudano More articles by this author Daniel J. Lee More articles by this author Fujun Zhao More articles by this author Bilal Chughtai More articles by this author Richard K. Lee More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...