MP35-05 IN-VIVO, PERCUTANEOUS, NEEDLE BASED, OPTICAL COHERENCE TOMOGRAPHY OF RENAL MASSES

Abstract

You have accessJournal of UrologyKidney Cancer: Evaluation and Staging I1 Apr 2015MP35-05 IN-VIVO, PERCUTANEOUS, NEEDLE BASED, OPTICAL COHERENCE TOMOGRAPHY OF RENAL MASSES Peter Wagstaff, Daniel de Bruin, Alexandre Ingels, Patricia Zondervan, Otto van Delden, Ton van Leeuwen, Jeroen van Moorselaar, Jean de la Rosette, and Pilar Laguna Peter WagstaffPeter Wagstaff More articles by this author , Daniel de BruinDaniel de Bruin More articles by this author , Alexandre IngelsAlexandre Ingels More articles by this author , Patricia ZondervanPatricia Zondervan More articles by this author , Otto van DeldenOtto van Delden More articles by this author , Ton van LeeuwenTon van Leeuwen More articles by this author , Jeroen van MoorselaarJeroen van Moorselaar More articles by this author , Jean de la RosetteJean de la Rosette More articles by this author , and Pilar LagunaPilar Laguna More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1106AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Optical coherence tomography (OCT) is a high resolution imaging technique, based on the backscattering of near infrared light. Within OCT scans the loss of light intensity per millimeter of tissue penetration, the attenuation coefficient (μOCT), can be calculated. We hypothesize that the μOCT is higher in malignant versus benign tumours, due to cellular changes that take place during carcinogenesis, providing the means for tissue differentiation. The aim of this study is to develop OCT into an instant and accurate technique for tumour differentiation. METHODS Percutaneous, image guided, needle based OCT of the kidney was performed in consecutive patients presenting with a solid renal mass. The OCT probe was delivered using a trocar needle piercing the tumour. After OCT scanning, conventional core biopsies were acquired. Additional pathology material, resection specimen or additional biopsies, is acquired during final treatment. Subsequently μOCT analysis is performed and correlated to histopathology results. RESULTS Until now 49 renal tumours were included, among which 46 percutaneous OCT scans were performed. Analysis of the first 10 cases shows a distinct difference (fig. 1) in the μOCT between benign tissue (AVG 2.86 mm-1, STDV 0.99) and malignant renal masses (AVG 3.90 mm-1, STDV 1.70). Visual evaluation of newly acquired OCT scans proved to be a valuable tool in confirming successful targeting (fig. 2). Analysis of the remaining cases will be performed as final pathology results become available in upcoming months. Fig. 1. Box plot of the μOCT of the first 10 OCT candidates. Fig. 2. The typical structure of perinephric fat on conventional pathology (A) and OCT imaging (B). The typical clustering of a renal oncocytoma on conventional pathology (C) and OCT imaging (D). CONCLUSIONS Percutaneous, needle based, OCT of renal masses is a safe and easy procedure. Analysis of the first 10 cases shows a distinct difference in the μOCT between benign tissue and malignant renal masses, providing the means for tumour differentiation. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e420-e421 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Peter Wagstaff More articles by this author Daniel de Bruin More articles by this author Alexandre Ingels More articles by this author Patricia Zondervan More articles by this author Otto van Delden More articles by this author Ton van Leeuwen More articles by this author Jeroen van Moorselaar More articles by this author Jean de la Rosette More articles by this author Pilar Laguna More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...