Abstract
INTRODUCTION AND OBJECTIVES: Neutrophil-to-lymphocyte ratio (NLR), a simple marker of systemic inflammatory response, has been demonstrated as an independent prognosticator for some solid malignancies. We investigated the utility of pretreatment NLR as a prognosticator in patients who presented with penile cancer. METHODS: A total of 122 patients who underwent radical penectomy in our institutions from 1988 to 2014 were analyzed. In these patients, 40 patients (32.8%) were performed CBCs before pathological diagnosis. The NLR was calculated using the patients’ neutrophil and lymphocyte counts before pathologically diagnosis of prostate cancer. We investigated the correlation between NLR and prognosis of penile cancer. RESULTS: The median and mean ( SD) NLR of 40 penile cancer patients were 3.42 and 5.03 4.99. The cut-off value was determined to be 2.82. Patients with high NLR showed significantly poorer CSS (p 1⁄4 0.023) compared with those with low NLR. CONCLUSIONS: Pretreatment NLR may function as a new biomarker that precisely predicts the prognosis in patients with penile cancer.
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