Abstract
BackgroundThe neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer.MethodsA total of 41 patients who underwent complete blood count with differential and subsequent radical penectomy from 1988 to 2014 were analyzed. We assessed the correlation between the NLR and the prognosis of penile cancer.ResultsThe median and mean (± SD) NLRs in 41 penile cancer patients were 3.42 and 5.03 ± 4.99, respectively. Based on the area under receiver operator characteristic curve, the cut-off value of NLR was determined to be 2.82. Patients with a high NLR (≥2.82) showed a significantly poorer cancer-specific survival (p = 0.023) than those with a low NLR.ConclusionsThe pretreatment NLR may function as a biomarker that precisely predicts the prognosis in patients with penile cancer.
Highlights
The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies
We investigated the utility of the pretreatment NLR as a prognosticator in patients who presented with penile cancer
Penile cancer patients showed a higher NLR According to the clinical database of the Department of Urology at Yokohama City University Hospital, 9782 patients underwent an NLR check during the study period
Summary
The neutrophil-to-lymphocyte ratio (NLR), a simple marker of the systemic inflammatory response, has been demonstrated to correlate with patient outcomes for various solid malignancies. The neutrophil-to-lymphocyte ratio (NLR) has been suggested as a simple marker of the systemic inflammatory response in critical care patients [7]. It has been reported as an independent prognostic factor for several solid malignancies [8,9,10,11,12,13,14,15,16,17]. The NLR can be calculated from routine complete blood counts (CBCs) in peripheral blood samples [15, 16]
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