MP26-10 CLINICAL AND METABOLIC FACTORS AFFECTING RELATIVE PROPORTION OF CALCIUM OXALATE MONOHYDRATE AND DIHYDRATE IN PURE CALCIUM OXALATE STONES

Abstract

You have accessJournal of UrologyCME1 May 2022MP26-10 CLINICAL AND METABOLIC FACTORS AFFECTING RELATIVE PROPORTION OF CALCIUM OXALATE MONOHYDRATE AND DIHYDRATE IN PURE CALCIUM OXALATE STONES Mohammad Hout, Vedant Acharya, Madhumita Parmar, Ruben Blachman Braun, Jonathan Katz, Robert Marcovich, and Hemendra Shah Mohammad HoutMohammad Hout More articles by this author , Vedant AcharyaVedant Acharya More articles by this author , Madhumita ParmarMadhumita Parmar More articles by this author , Ruben Blachman BraunRuben Blachman Braun More articles by this author , Jonathan KatzJonathan Katz More articles by this author , Robert MarcovichRobert Marcovich More articles by this author , and Hemendra ShahHemendra Shah More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002569.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Calcium oxalate stone are the commonest variety of urinary calculi. Patients contain varying amount of its sub-types- calcium oxalate monohydrate and dihydrate. Few studies from past demonstrate varying metabolic defects in patients with both sub-types. The aim of present study was to study influence of various clinical and metabolic factors on relative proportion of calcium oxalate monohydrate and dihydrate in pure calcium oxalate stones. METHODS: We retrospectively examined stone analysis report of all patients who underwent endourological procedure for stone removal at our center from Jan 2017 to December 2019. Stones made of pure calcium oxalate with varying proportion of its subtypes were identified. Patient with combination of calcium oxalate with other components were excluded from study. Chart review was performed of all this patient to identify those who had 24-hour urinary stone risk profile done within 3 month of stone analysis and prior to start of medical management of stone. Statistical analysis was performed using SPSS 24. Correlational analysis between stone composition and clinical and metabolic variables was performed with the Spearman test. RESULTS: Of 120 calcium oxalate stones, 66 contained > 60% monohydrate and 8 contained > 60% dihydrate. The mean age in patients with dihydrate stone was 39.6 + 17 and monohydrate was 55.3 + 14.6. (P=0.002). Correlation analysis suggested that age, BMI and urinary Ph. Calcium oxalate saturation, brushite saturation and uric acid saturation were found to have significant co-relation with percentage of calcium oxalate dihydrate or calcium oxalate monohydrate stone composition (Figures 1 and 2). CONCLUSIONS: Calcium oxalate dihydrate stones former are younger and have lower BMI than those with monohydrate stones. Similarly as urinary Ph become more alkaline, the relative proportion of dihydrate increases. Source of Funding: none © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e442 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mohammad Hout More articles by this author Vedant Acharya More articles by this author Madhumita Parmar More articles by this author Ruben Blachman Braun More articles by this author Jonathan Katz More articles by this author Robert Marcovich More articles by this author Hemendra Shah More articles by this author Expand All Advertisement PDF DownloadLoading ...