MP25-01 RELATIONSHIP BETWEEN TESTOSTERONE AND PROSTATITIS-LIKE SYMPTOMS ASSESSED BY THE NATIONAL INSTITUTES OF HEALTH CHRONIC PROSTATITIS SYMPTOM INDEX

Abstract

You have accessJournal of UrologyInfections/Inflammation of the Genitourinary Tract: Prostate & Genitalia1 Apr 2015MP25-01 RELATIONSHIP BETWEEN TESTOSTERONE AND PROSTATITIS-LIKE SYMPTOMS ASSESSED BY THE NATIONAL INSTITUTES OF HEALTH CHRONIC PROSTATITIS SYMPTOM INDEX Gyeong Eun Min, Jun Ho Lee, Koo Han Yoo, Dong-Gi Lee, and Hyung-Lae Lee Gyeong Eun MinGyeong Eun Min More articles by this author , Jun Ho LeeJun Ho Lee More articles by this author , Koo Han YooKoo Han Yoo More articles by this author , Dong-Gi LeeDong-Gi Lee More articles by this author , and Hyung-Lae LeeHyung-Lae Lee More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1204AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recently, it has been reported that chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is related to decreased vascular endothelial dysfunction and cardiovascular disease. Testosterone has been suggested to play a role in vascular endothelial dysfunction and cardiovascular disease. Considering the relationship of testosterone and CP/CPPS with endothelial dysfunction and cardiovascular disease, there may also be a relationship between testosterone and CP/CPPS. Therefore, we evaluate their relationship. METHODS A total of 9180 middle aged men who had participated in a health examination were included. The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was administered to evaluate prostatitis-like symptoms. Symptoms were regarded as mild pain if respondents reported perineal or ejaculatory pain and had an NIH-CPSI pain score ≥4 but <8 and the symptoms were considered moderate to severe pain if the pain score was ≥8. A full metabolic work-up and serum testosterone level checks by RIA. The Mantel-Haenszel Extension test, multiple linear regression tests, and logistic regression analyses were used. RESULTS The mean age was 52.3±9.4 years, and the mean serum testosterone level was 5.3±1.6 ng/mL. The number of man with late onset hypogonadism (LOH: testosterone <3.5 ng/mL) was 1037 (11.3%). In total, 1643 (17.9%) men had prostatitis-like symptoms, and 650 (7.1%) men had moderate to severe symptoms. The ages and components of the metabolic syndrome adjusted mean NIH-CPSI total score and NIH-CPSI pain score was significantly higher in the LOH group (mean (95%CI): total score: 9.26 (8.86-9.66) vs. 8.65 (8.50-8.80); P=.005; pain score: 3.90 (3.75-3.66) vs. 3.72 (3.70-3.75); P=.026). There was a significant increase in the incidence of LOH as the severity of prostatitis-like symptoms increased (positive ratio: no pain, 11.0%; mild pain, 11.4%; moderate to severe pain 14.5%; P trend=.019). Additionally, odds ratio for LOH was significantly associated with prostatitis-like symptoms and moderate to severe prostatitis-like symptoms after adjusting for potential confounding factors (mild prostatitis-like symptoms, OR for LOH: 1.074, 95% confidence interval:.904-1.275; moderate to severe symptoms, OR for LOH: 1.394: 95% confidence interval: 1.104-1.762). CONCLUSIONS LOH was significantly correlated with the presence and severity of prostatitis-like symptoms. Further researches would be needed to elucidate the role of testosterone in developing CP/CPPS. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e285 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Gyeong Eun Min More articles by this author Jun Ho Lee More articles by this author Koo Han Yoo More articles by this author Dong-Gi Lee More articles by this author Hyung-Lae Lee More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...